Biosynthesis of aspergillic acid.
نویسنده
چکیده
of aspergillic acid from isoleucine in replacement cultures (3), there has been no work reported previously on the biogenesis of this antibiotic. In the present work, A. flavus was grown on a medium containing radioactive leucine or isoleucine, and these compounds were found to be incorporated into the aspergillic acid formed. Aspergillic acid was degraded to determine what part of the molecule contained the isotope and to determine the optical configuration of the set-butyl side chain.
منابع مشابه
Aspergillic Acid: an Antibiotic Substance Produced by Aspergillus Flavus I. General Properties; Formation of Desoxyaspergillic Acid ; Structural Conclusions by James D. Dutcher
The discovery by White (1) in 1940 that a strain of Aspergillus Jlavus, growing in surface culture on a tryptone-salt medium, produced a highly bactericidal filtrate from which White and Hill in 1943 (2) were able to isolate the active material in crystalline form added another member to the increasing group of chemically and biologically interesting antibiotic compounds. Because the mode of is...
متن کاملAspergillic Acid: an Antibiotic Substance Produced by Aspergillus Flavus I. General Properties; Formation of Desoxyaspergillic Acid ; Structural Conclusions by James D. Dutcher
The discovery by White (1) in 1940 that a strain of Aspergillus Jlavus, growing in surface culture on a tryptone-salt medium, produced a highly bactericidal filtrate from which White and Hill in 1943 (2) were able to isolate the active material in crystalline form added another member to the increasing group of chemically and biologically interesting antibiotic compounds. Because the mode of is...
متن کاملProduction of Aspergillic Acid by Surface Cultures of Aspergillus flavus.
It has been reported by White (1940), Rake, McKee, and Jones (1942), White and Hill (1943), Jones, Rake, and Hamre (1943), and Bush, Dickison, Ward, and Avery (1945) that the fungus Aspergillusflavus produces an antibiotic substance known as aspergillic acid. Aspergillusflavus is also known to produce other antibiotic substances such as flavacidin (McKee, Rake, and Houck, 1943; McKee and MacPhi...
متن کاملAspergillic acid; an antibiotic substance produced by Aspergillus flavus.
The discovery by White (1) in 1940 that a strain of Aspergillus Jlavus, growing in surface culture on a tryptone-salt medium, produced a highly bactericidal filtrate from which White and Hill in 1943 (2) were able to isolate the active material in crystalline form added another member to the increasing group of chemically and biologically interesting antibiotic compounds. Because the mode of is...
متن کاملInterference with valine and isoleucine biosynthesis by cyclic hydroxamic acids.
Hogg, Robert W. (University of Illinois, Urbana), Chitra S. Biswas, and Harry P. Broquist. Interference with valine and isoleucine biosynthesis by cyclic hydroxamic acids. J. Bacteriol. 90:1265-1270. 1965.-The introduction of a hydroxyl group in a number of common barbiturates, a substitution which converts these compounds to cyclic hydroxamic acids, gives rise to compounds which inhibit growth...
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 236 شماره
صفحات -
تاریخ انتشار 1961